For safety PDRN, BR Pharm PDRN certified of API, Active Pharmaceutical Ingredient and DMF registered by Ministry of Food and Drug Safety institution
One day a fisherman living in a small fishing village got a serious injury during working.
But there was lack of medical facility in a small fishing village.
So fishermen squeezed out the sperm from salmon fish and applied it to the wound area several times regularly. It was kind of cure action treatment like folk remedies from an ancestor in a fishing village, and finally found out wound healing perfectly without any inflammation. And a doctor who is seen this situation, studied and researched it, and discovered PDRN.
PolyDeoxyRiboNucleotide, as a substance, it is very few substances in the human placenta, and ethical issues and difficulties of the medicine productivity, therefore PDRN in the fish has emerged as an alternative. The components of the PDRN are taken in small quantities from the sperm of Sea trout. It is a DNA segment that is 95% match with human DNA and selectively acts on the adenosine A2 receptor to induce tissue regeneration and anti-inflammation effectiveness.
Sea trout sperm DNA
Human DNA like
Cell growth promoter
PDRN Mechanisms of Action
PDRN mechanism & effect Selectively act to adenosine A2 receptor in cells
Increase Growth Factor
Suppress pro-inflammatory cytokine
Induce rapid DNA synthesis and cell regeneration with less energy
Promotes the secretion of various growth factors (FGF, IGF, etc.), and promotes the differentiation of
Vasodilation and microvascular generation
Promote synthesis of damaged DNA
Promote inflammation relief
's Safe PDRN
Seawater domestication required for sea farming
Sea trout(Oncorhynchus mykiss) homing migration process
Fresh water, Sea water
2nd freshwater (osmoregulation)
Spawning from October to March of the following year
Cold water fish
PDRN component contained in male sea trout testes.
Natural Sea trout
Nature sea trout do not know what they have eaten during homing migration process
It can be exposed to risks such as parasitic, bacterial, viral diseases, and it is inappropriate for use as a raw material for medicines. BR Pham is the first company who achieves successful sea trout farming for extraction of raw materials with medicine through collaborative work by technical guidance of the Jeollanam-do institute of ocean & fisheries technology and BR Pharm’s own technology.
Sea trout farm
PDRN raw material - Sea trout Farm
1. Raw material’s Traceability possible farm methods
2. The Area(the south coast) where Clean Seawater supply is easy
3. The Best area for securing seawater and fresh water essential for
Development of Seawater domestication technology
The trout is a secondary freshwater fish that has an ability to control osmosis, so it is necessary to adjust the period of adaptation when spawning at the point either the freshwater and freshwater fish or pass through the fresh water and the sea water
Secondary fresh fish water
Non-antibiotic farming technology development
Hazard Analysis and Critical Control Point system(HACCP), Quality Management Systems ISO 9001 acquired, Seafood Traceability System, Bio Floc System(BFT), functional feed utilized and reliable pharmaceutical raw material production with Non-antibiotic farming
Sea circulation & filtration system
remove solid foreign substance, and
remove harmful substances dissolved in water by supplying Biofloc EM microbes.
Prevent environment pollution which is caused by effluent water is reduced greatly because the breeding water is not exchanged or minimized.
Prevent infectious disease inflow through breeding water. Conservation of heating costs. Efficient energy use.
Increase breeding density to increase the productivity of aquaculture, increase feed efficiency (FCR).
Strict quality control management
For Non-Antibiotic, Development of juicy eco-friendly feed
Average in July: Size 40.3cm, weight 807g
Average in July: Size 41.9cm, weight 936g
Health checkup &
Blood sampling for health analysis
Internal organs tissue collection
Check gonadal maturation status
Selected raw materials for pharmaceuticals
Acquisition: All processing Quality Control
Passed conformity determination -
Bacterial and antibiotic not detected
BR Pharm’s selective testicles
PDRN unique extraction technology – own patent application
Raw material in stock
Fracture and urification
Precipitate recovery / washing
Check virus extinction while processing_No virus!
PDRN Safety : Not cytotoxic on MRC-5 and Vero cell line
It is proved that 4 kinds of viruses are eliminated in final product inactivation and spiking test.
Salmon virus 2 types/ Human virus 1 types / Porcine virus 1 types
Add virus during production
The birth of BR Pharm PDRN raw material medicine : VITARAN
BRPHARM’s eco-friendly and safe process
Unique PDRN extraction technology from sea trout sperm
through BGMP system
PDRN raw material : Virus inactivation test
No detection of virus from BR PHARM’s PDRN raw material
2017. 12 by BIO PS Biopharmaceutical Safety Verification Center
Passed strict quality control
BR Pharm PDRN. API DMF registered.
DMF registered by Ministry of Food and Drug Safety institution
BR Pharm PDRN Raw material medicine DNA size separation purification technology
Musculoskeletal disorders treatment
BRPHARM PDRN Business Area
Cell growth activator
Supplying various functional solutions to 3500 domestic clinics
Anti-aging, skin care Cosmetics
Establish food production facility (3rd factory) - Scheduled
BR PHARM Co.,Ltd. I Representative : Kim Seok Soon I Business License Neumber : 122-81-87742
Tel : +82-2-2148-6700 I Fax : +82-2-2148-6777 I E-mail :firstname.lastname@example.org
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